Economic regulation in the United States dates back to the late 1800s, and the landscape continues to evolve today. Recent U.S. Supreme Court cases have addressed federal government regulation in areas such as product labeling, telecommunications, and healthcare. In Colorado, several current topics center on regulation and the interplay between state and local government. This article will describe the Colorado state regulatory process and highlight two areas of national interest—marijuana and oil and gas—playing out in our state. Lawyers practicing in these areas will be familiar with the industries, government agencies, and trends discussed below.